JUSTIFICATION OF THE COMPOSITION OF THE COMBINED VEGETABLE HYPOGLYCEMICAL REMEDY
DOI:
https://doi.org/10.32689/2663-0672-2023-5-21Keywords:
herbal medicines, diabetes, hypoglycemic agents, prediction of biological activity.Abstract
Abstract. Formulation of the problem. Type 2 diabetes is a serious medical and social problem, the prevalence of which is increasing with numerous debilitating complications. In the treatment and prevention of type 2 diabetes, the use of herbal medicine is becoming more and more important. In Ukraine, the list of official antidiabetic drugs of plant origin is limited. Analysis of recent research and publications. Attention to the role of herbal medicines in the treatment of diabetes is constantly increasing. The analysis of publications shows that phytotherapy should be a mandatory component in the treatment of diabetes, since in many cases it prevents the development of cardiovascular system lesions, diabetic neuro-, retinopathy, kidney and liver lesions or postpones the appearance of these pathologies. Formulation of the purpose of the article. The aim of the study is to evaluate the probable pharmacological potential of the biologically active substances of the plants Momordica charantia, Gymnema sylvestre, Enicostemma littorale using in silico resources and theoretical justification of their pharmacological activity. Presentation of the main research material. The biological activity of the compounds contained in the extracts of Momordica charantia, Gymnema sylvestre, and Enicostemma littorale was predicted. An acute toxicity analysis for rats was performed using the GUSAR program. Selected compounds were tested for compliance with Lipinski's criteria. The studied compounds can be used as candidate compounds for the creation of medicinal products. Conclusions. When predicting biological activity, the studied biologically active substances Momordica charantia, Gymnema sylvestre, Enicostemma littorale revealed antidiabetic, hypoglycemic, hypolipidemic, antitumor, hepatoprotective, and chemopreventive activity. The indicators of acute toxicity of the studied substances were calculated. Correspondence of the investigated biologically active substances to the pharmacokinetic indicators was established. The composition of the combined hypoglycemic drug is proposed.
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