STUDY OF THE EFFECT OF VACCINATION AGAINST COVID-19 ON THE CLINICAL COURSE OF CORONAVIRUS DISEASE IN PATIENTS WITH ACUTE CORONARY SYNDROME
DOI:
https://doi.org/10.32689/2663-0672-2024-4-2Keywords:
acute coronary syndrome, coronavirus disease, clinical course, risk of complications, 30-day mortalityAbstract
In this article, the scientific problem is focused on establishing associative links between vaccination against COVID-19 and the clinical course and complications of acute coronary syndrome. A detailed review of foreign studies was conducted to study the available global experience of the impact of vaccination against COVID-19 on the course and complications of acute coronary syndrome. Aim. The purpose of the work is to determine the impact of vaccination against COVID-19 on the course and complications of acute coronary syndrome. Scientific novelty. For the first time, the impact of vaccination against COVID-19 on the course and complications of acute coronary syndrome was studied. Materials and methods: analysis of theoretical sources, comparison of formed groups of study participants: the main group (n=50), which included patients with acute coronary syndrome against the background of clinical manifestation of COVID-19, the presence of which was confirmed in a cardiac surgical hospital, and a comparison group (n= 50) – patients with acute coronary syndrome without signs of respiratory viral diseases, with a negative result of the polymerase chain reaction test for COVID-19; deduction of consequences from the hypothesis with clarification of its content; experimental verification of the consequences derived from the hypothesis. Conclusions. It was found that the number of people vaccinated against COVID-19 was significantly higher in the comparison group, with the study participants preferring the Pfizer and AstraZeneca vaccines and 72.9% of the sample patients having received the full vaccination course. Analysis of the clinical course showed that moderate COVID-19 was common in the vaccinated patients of the main group, and the severe course was significantly higher in the unvaccinated. It was found that the presence of complications was probably higher among unvaccinated patients of the main group, which increases the risk of developing complications. 30-day mortality was found to be significantly higher among patients in the main group, but was not associated with vaccination against COVID-19.
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