ALZHEIMER'S DISEASE: MICROBIOLOGICAL ASPECTS OF THE COURSE
Keywords:
Alzheimer's disease, intestinal microflora, indigenous microfloraAbstract
Formulation of the problem. The study of the relationship between the intestines and the brain in Alzheimer's disease (BA) is relevant today. Analysis of recent research. According to experts of the World Health Organization, BA is the most common cause of dementia in the elderly and the elderly. Nowadays there is an increasing number of evidence that the immune system is involved in the development of BA disease. There is a grandiose and irreversible atrophy of the zone of recognition, analysis and preservation of information in the corresponding sections of the brain. Recent studies have shown the involvement of neuro-spasm in the pathogenesis of asthma.
Formulating the purpose of the article. The purpose - to study the qualitative and quantitative composition of the intestinal microflora of patients with bronchial asthma.
Presenting main material. Analyzing the results of the microbiological study of feces in patients with bronchial asthma, we found that in 100% of the patients examined, qualitative and quantitative dysbiotic changes of the intestine of various degrees of manifestations were revealed: in the cases of grade I dysbiosis recorded in 38,1 ± 0,04% of cases; in 28,6 ± 0,03% - II degree and in 33,3 ± 0,03% - the third degree.
Conclusions and perspectives of further research. In 25,0 ± 0,1% of patients in group 1, an intestinal dysfunction, which was manifested as diarrhea, was recorded in history. In patients of the 2nd and 3rd groups, subcompensated and decompensated forms of dysbiosis were reported jointly, characterized by an increase in the degree of colonization of the intestines of the UPM and a decrease in colonization resistance mediated by an indigenous microflora. Prospects for further research are the study of the immune status of patients with bronchial asthma; conducting in vivo studies on the influence of its own microflora on the nature and rate of microbioma correction in intestinal dysbiosis in comparison with probiotic therapy.
References
Бачинская Н.Ю. Болезнь Альцгеймера / Н.Ю. Бачинская // Журнал неврології ім. Б.М. Маньковського. – № 1. – 2013. – С. 88–102.
Боголепова А.Н. Болезнь Альцгеймера и сахарный диабет / А.Н. Боголепова // Медицинский совет. – № 18. – 2015. – С. 36–40.
Кухарский М.С. Молекулярные аспекты патогенеза и современные подходы к фармакологической коррекции Болезни Альцгеймера / М.С. Кухарский, Р.К. Овчинников, С.О. Бачурин // Журнал неврологии и психиатрии. – № 6. – 2015. – С. 103–111.
Avila J. Role of tau protein in both physiological and pathological conditions / J. Avila, J.J. Lucas, M. Perez, F. Hernandez // Physiol. Rev. – Vol 84. – 2004. – P. 361–384.
Alonso А.С. Polymerization of hyperphosphorylated tau into filaments eliminates its inhibitory activity / A.C. Alonso, B. Li, I. Grundke-Iqbal, K. Iqbal // PNAS. – Vol. 103(23). – 2006. – P. 8864–8869.
Соколік В.В. Молекулярнi засади тауопатii у патогенезi хвороби Альцгеймера / Соколік В.В. // Матеріали ХІІ Конґресу. Світової федерації українських лікарських товариств. – Івано-Франківськ, 2008. – С. 259–260.
McGeer E.G. Inflammatory process in Alzheimer’s disease / E.G. McGeer, P.L. McGeer // Progress in NeuroPsychopharmacology and Biological Psychiatry. – Vol. 27(5). – 2005. – P. 741–749.
Shaftel S.S. Sustained hippocampal IL-1 beta overexpression mediates chronic neuroinflammation and ameliorates Alzheimer plaque pathology / S. S. Shaftel, S. Kyrkanides, J. A. Olschowka // J. Clin. Invest. – Vol. 117(6). – 2007. – P. 1595–1604.
Akama K.T. Beta-amyloid stimulation of inducible nitric-oxide synthase in astrocytes is interleukin-1beta- and tumor necrosis factor-alpha ... and involves a TNFalpha receptor-associated factor- and NFkappaB-inducing kinase-dependent signaling mechanism / K.T. Akama, L.G. Van Eldic // J. Biolog. Chemestry. – Vol. 275(11). – 2000. – P. 7913–7924.
МУ «Микробиологическая диагностика дисбактериоза кишечника. – М. – 2007. – 70 с.
Кишечная микрофлора : роль в поддержании здоровья и развитии патологии, возможности коррекции : учеб.-метод. пособие / Р. В. Хурса, И. Л. Месникова, Я. С. Микша. – Минск : БГМУ, 2017. – 36 с.
Reddy B.S. Inhibitory effect of Bifidobacterium longum on colon, mammary, and liver carcinogenesis induced by 2-amino-3-methylimidazo-4,5 quinoline, a food mutagen / B.S. Reddy, A. Rivenson // Cancer Res. – 1993. – Vol. 53. – P. 3914–3918.
Sreekumar O. The antimutagenic of properties of a polysaccharide produced by Bifidobacterium longum and its cultured milk against some heterocyclic amines / O. Sreekumar, A. Hosono // Can. J. Microbiol. – 1998. – Vol. 44. – P. 1029–1036.
The effect of fermented milk conteining Lactobacillus casei on the immune response to exercise / P.Pujol, J. Huguet, M.Banquells et al. // Sport. Med. Training Rehab. – 2000. – Vol. 6. – P. 1–15.
Goldin B.R. The effect of milk and lactobacillus feeding on human intestinal bacterial ensime activity / B. R. Goldin, S. Gorbach // J. Clin. Nutral. – 1984. – Vol. 6. – P. 756–761.
A trial in the Karelian Republic of oral rehydration and Lactobacillus GG for treatment of acute diarrhoea / A.V.Shornikova, E.Isolauri, L.Burkanova et al. // Acta Paediatr. – 1997. – Vol. 86. – P. 460–465.
O’Mahony S.M. Maternal separation as a mode of brain-gut axis dysfunction / S.M. O’Mahony, N.P. Hyland, T.G. Dinan et al. // Psychopharmacoogy (Berl.). – 2011. – Vol. 214. – P. 71–88.
Бондаренко В.М. Значение нервной системы при воспалительных заболеваниях кишечника / В.М. Бондаренко, Е.В. Рябиченко // Журн. микробиол. – 2011. - № 1. – С. 92–100.
Wang Yan. The role of microbiome in central nervous system disorders / Yan Wang, Lloyd H. Kasper// Brain Behav Immun. – 2014. – Vol. 38. – P. 1–12.
Sudo N. Postnatal microbial colonization programs the hypothalamic-pituitary - adrenal system for stress response in mice / N. Sudo, Y. Chida, Y. Aiba [et al.] // J Physiol. – 2004. - Vol. 558 (1). - P. 263–275.
The QseC sensor kinase: a bacterial adrenergic receptor / M.B. Clarke, D.T. Hughes, C. Zhu et al. // Proceedings of the National Academy of Sciences of the United States of America. – 2006. – Vol. 103. – P. 10420–10425.
