PARTICIPATION OF FUNCTIONAL BODY SYSTEMS IN THE DEVELOPMENT OF THE PERIODONTITIS MODEL

Abstract

Actuality. Periodontitis is the most common dental pathology. It affects almost half of the adult population of the Earth. Modern drug treatment of periodontitis does not achieve the desired results and often causes quite serious side effects. More and more dentists are turning their attention to herbal medicines. It would be rational to use natural modulators of plant origin in the treatment of patients with periodontitis. One of such modulators is amaranth oil. Amaranth normalizes affected tissues, corrects impaired immune regulation; activates the antimicrobial and fungicidal activity of the immune system. The purpose of the study. Determination of the presence and relationship of disorders in the peripheral blood system and metabolism in rats with a periodontal disease model. Research materials and methods. The authors studied changes in the functional systems of the rat body, peripheral blood, and metabolism during simulation of periodontal disease. The work was performed on 42 white rats of the Wistar line of autobred breeding with a body weight of 180–200. Work with animals was carried out in accordance with the requirements of the «European Convention on the Protection of Animals, we use them for scientific purposes (directive 2010\63\EU of the European Parliament and the Council of 22.09.2010) and the order of the Ministry of Education, Science, Youth and Sports dated 06.04.22 No. 249». The results of the study proved that the development of the periodontitis model in rats is accompanied by changes in the studied functional systems in the form of signs of inflammatory reactions, increased phagocytosis, deterioration of the rheological properties of peripheral blood. Among the metabolic reactions, there is inhibition of protein synthesis activity, a decrease in the energy supply of transmembrane transport; activation of POL; impaired activity of the NO synthase system. Conclusions. The authors believe that the identified changes indicate the systemic nature of the pathogenesis of periodontitis, and changes in functional systems create a pathological background for the development of local periodontal damage.