CHICKENPOX AND PREGNANCY
DOI:
https://doi.org/10.32689/2663-0672-2025-1-14Keywords:
сhickenpox, pregnancy, childrenAbstract
The article is devoted to the study of the problem of Chickenpox in pregnancy. Chickenpox is a common not a severe childhood illness but if this develops in pregnancy it is associated with serious adverse sequelae such as congenital varicella syndrome, maternal VZV pneumonia and neonatal varicella infection which may lead to feto-maternal morbidity and mortality. The aim of this study is to analyze and systematize data on the problem of Varicella Zoster Virus (Chickenpox) Infection in Pregnancy. Materials and methods. The materials of the study were international and national concepts and strategies, regulatory documents, clinical guidelines, information from scientific databases such as Scopus, Web of Science, Cochrane Library, PubMed. The methods of comparative analysis, systematization and generalization of information on the problem of Chickenpox in pregnancy were used. Results and discussion. Chickenpox is a common infectious disease, usually mild in children and more severe, complicated, and even fatal in adults. Chickenpox during pregnancy is not very common, but despite this, it remains a serious problem for this category of patients, associated with the development of pneumonia, hepatitis, encephalitis, and leads to 2% mortality among mothers. Mortality from maternal chickenpox pneumonia can range from 3-14% to 20-45%, depending on whether timely therapy was initiated. Clinical forms of intrauterine chickenpox are Сongenital Varicella Syndrome (CVS) and Neonatal Varicella. The severity of clinical manifestations in the fetus and newborn will depend on many factors: gestational age, form of infection in the mother, severity of the disease, presence of concomitant pathology in mother. In the medical literature of recent years, there is not much systematic data on this problem, and the seriousness of the adverse effects makes it necessary to study this issue in more depth. Conclusions. The necessity of a more significant study of the problem of Chickenpox in Pregnancy, complications, clinical manifestations has been substantiated.
References
Богадельников І. В. Роль герпесвірусної інфекції в організмі людини. Сучасні медичні технології. 2009. № 3. С. 57–61.
Вітряна віспа : клінічна настанова, заснована на доказах. 2016. С. 7–34. URL: https://www.dec.gov.ua/wpcontent/uploads/2019/11/akn_vv.pdf
Крамарьов C. О., Палатна Л. О., Воронов О. О., Головач О. В., Селіверстова К. А., Лисий А. В. Вроджена вітряна віспа у дітей: особливості сучасного перебігу, випадки з практики. Дитячий лікар. 2017. 5-6 (56-57). С. 5–10. URL: https://d-l.com.ua/uploads/issues/2017/5-6(56-57)/DL175-6_5-9_383d1927f3b16be89908705f54ef631b.pdf
Маврутенков В. В., Плеханова Т. Н., Белозерова В. Л., Соколова Е. Ю. Varicella-Zoster вірусна інфекція у новонароджених. Неонатологія, хірургія та перинатальна медицина. 2013. Т. III. № 3 (9). С. 145–151.
Матейко Г. Б., Антонюк Л. В., Ігнатовська С. П. Сучасні уявлення про материнсько-плодову Варіцела-Зостер вірусну інфекцію. Інфекційні хвороби. 2015. 4 (82). С. 74–78. URL: https://ojs.tdmu.edu.ua/index.php/inf-patol/article/view/5522/5053
Advisory Committee on Immunization Practices. Recommended adult immunization schedule: United States, 2011. Annals of Internal Medicine. 2011. Vol. 154. № 3. P. 168–173.
Akisu M., Yalaz M., Aksu G., Arslanoglu S., Genel F., Kutukculer N. Maternally acquired varicella-zoster virus antibodies disappear at 6 months of age in prematurely born children. Panminerva Medica. 2003. 45 (2). Р. 155–156.
Birthistle K., Carrington D. Fetal varicella syndrome--a reappraisal of the literature. A review prepared for the UK Advisory Group on Chickenpox on behalf of the British Society for the Study of Infection. Journal of Infection. 1998. 36 (1). Р. 25–29. DOI: 10.1016/s0163-4453(98)80152-7.
Chickenpox and pregnancy. 2024 URL: https://www.rcog.org.uk/for-the-public/browse-our-patient-information/chickenpox-and-pregnancy/
Chickenpox. Questions and answers. 2025 URL: https://www.who.int/news-room/questions-and-answers/item/chickenpox#:~:text=These%20blisters%20eventually%20dry%20out,range%20of%2010%E2%80%9321%20days.
Enders G., Miller E. Varicella and herpes zoster in pregnancy and the newborn. In: Arvin AM, Gershon AA, editors. Varicella-Zoster Virus Virology and Clinical Mangement. Cambridge University Press. 2000. Р. 317–347.
Frisch S., Guo A. Diagnostic Methods and Management Strategies of Herpes Simplex and Herpes Zoster. Clinics in Geriatric Medicine. Philadelphia, 2013. № 29. P. 29-33.
Gardella C., Brown Z. A. Managing varicella zoster infection in pregnancy. Cleveland Clinic Journal of Medicine. 2007. 74 (4). Р. 290–296. DOI: 10.3949/ccjm.74.4.290.
Hall S., Maupin T., Seward J., Jumaan A.O., Peterson C., Goldman G. Second varicella infections: are they more common than previously thought? Pediatrics. 2002. 109 (6). Р. 1068–1073. DOI: 10.1542/peds.109.6.1068.
Lamont R. F., Sobel J. D., Carrington D., Mazaki-Tovi S., Kusanovic J. P., Vaisbuch E., Romero R. Varicella Zoster Virus (Chickenpox) Infection in Pregnancy. An International Journal of Obstetrics & Gynaecology. 2011. 118 (10). Р. 1155–1162. DOI: 10.1111/j.1471-0528.2011.02983.x
Mattson S. N., Jones K. L., Gramling L. J., Schonfeld A. M., Riley E. P., Harris J. A. Neurodevelopmental follow-up of children of women infected with varicella during pregnancy: a prospective study 1. The Pediatric Infectious Disease Journal. 2003. 22 (9). Р. 819–823. DOI: 10.1097/01.inf.0000086402.18710.54.
McCormack T., Webster C. Varicella Zoster infection. 2024. URL: https://teachmeobgyn.com/pregnancy/medicaldisorders/infections/varicella-zoster/
Nathwani D., Maclean A., Conway S., Carrington D.Varicella infections in pregnancy and the newborn. A review prepared for the UK Advisory Group on Chickenpox on behalf of the British Society for the Study of Infection. Journal of Infection. 1998. 36 (1). Р. 59–71. DOI: 10.1016/s0163-4453(98)80156-4.
Paller S. A., Mancini A. M. Hurwitz Clinical Pediatric Dermatology. Saunders-Elsevier, 2010. P. 348–370.
Paryani S. G., Arvin A. M. Intrauterine infection with varicella-zoster virus after maternal varicella. New England Journal of Medicine. 1986. 314 (24). Р. 1542–1546. DOI: 10.1056/NEJM198606123142403.
Pastuszak A. L., Levy M., Schick B., Zuber C., Feldkamp M., Gladstone J. Outcome after maternal varicella infection in the first 20 weeks of pregnancy. New England Journal of Medicine. 1994. 330 (13). Р. 901–905. DOI: 10.1056/NEJM199403313301305.
Prober C. G., Gershon A. A., Grose C., McCracken G. H., Nelson J. D. Consensus: varicella-zoster infections in pregnancy and the perinatal period. The Pediatric Infectious Disease Journal. 1990. 9 (12). Р. 865–869.
Sampathkumar P., Drage L.A., Martin D.P. Herpes zoster (shingles) and postherpetic neuralgia. Mayo Clinic Proceedings. 2009. Vol. 84. № 3. P. 274–280.
Sauerbrei A., Wutzler P. Varicella-Zoster Virus Infections During Pregnancy: Epidemiology, Clinical Symptoms, Diagnosis, Prevention and Therapy. Current Pediatric Reviews. 2005. 1. Р. 205–215.
Shapiro E. D., Vazquez M., Esposito D. Effectiveness of 2 doses of varicella vaccine in children. Journal of Infectious Diseases. 2011. Vol. 203, № 3. P. 312–315.
Schmader K. E., Levin M. J., Gnann J. W.Jr. Efficacy, safety, and tolerability of herpes zoster vaccine in person saged 50-59 years. Clinical Infectious Diseases. 2012. Vol. 54. № 7. P. 922–928.
Tan M. P., Koren G. Chickenpox in pregnancy: revisited. Reproductive Toxicology. 2006. 21 (4). Р. 410–420. DOI: 10.1016/j.reprotox.2005.04.011.
Tseng H. F., Smith N., Harpaz R. Herpes zoster vaccine in older adults and ther is kofs ubsequent herpes zoster disease. JAMA. 2011. Vol. 305. № 2. P. 160–166.
Тyring S. K. Management of herpes zoster and postherpetic neuralgia. Journal of the American Academy of Dermatology. 2007. Vol. 57 (6). P. 136–142.
Varicella Infection. Organization of Teratology Information Services. 2023. URL: https://mothertobaby.org/fact-sheets/varicella/
Weston W. L., Lane A. Т., Morelli J. G. Color textbook of Pediatric Dermatology. Mosby, 2007. P. 113–138.
Whitley R. J., Gnann J. W.Jr. Herpes zoster in the age of focused immunosuppressiv et terapy. JAMA. 2009. Vol. 301. № 7. P. 774–775.
Wilson J. F. Herpes zoster. Annals of Internal Medicine. 2011. Vol. 154. № 5. P. 15–31.
Yawn B.P., Wollan P.C., Kurland M.J. Herpes zoster recurrences more frequent than previous lyre ported. Mayo Clinic Proceedings. 2011. Vol. 86. № 2. P. 88–93.