AUTOTRANSPLANTATION AS A POSSIBILITY TO THE REHABILITATION OF DENTOMAXILLARY DEFECTS (LITERATURE REVIEW)
DOI:
https://doi.org/10.32689/2663-0672-2025-3-15Keywords:
autotransplantation, tooth transplantation, surgical techniques, complications, digital technologies, literature reviewAbstract
Restoring dentoalveolar defects is one of the key challenges in modern dentistry. Tooth autotransplantation – the relocation of a patient`s own tooth to another socket – is considered a promising treatment option that combines functional efficiency with natural tissue integration. Despite its proven clinical success, this method remains underutilized, highlighting the need to summarize current data on its indication's techniques, and outcomes. Objective. To analyze and summarize current scientific literature and clinical data on the effectiveness, indications, executing protocols, and prognosis of tooth autotransplantation as a biologically sound method for the restoration of dental arch defects. Methods. In order to form the primary initial sample of publications, a search for such publications was conducted using the Google Scholar (https://scholar.google.com/), PubMed (https://pubmed.ncbi.nlm.nih.gov/), ResearchGate (https://www. researchgate.net/) with the following set of keywords: “autotransplantation”, “tooth transplantation”, “autotransplantation complications” “surgical technique”. Results. As a result of the literature review, key aspects of tooth autotransplantation as a clinical treatment method were systematized. It was established that the success of the procedure depends on careful patient and donor tooth selection, atraumatic extraction techniques, precise planning and strict adherence to surgical protocols. The most frequently reported complications include ankylosis, external root resorption, and pulp necrosis. The review also analyzed the role of modern digital technologies in the planning and execution of autotransplantation, which contribute to improved accuracy and predictability of outcomes. Overall, the finding confirm the high clinical efficacy of the method, provided that all stages of treatment are properly followed. Conclusions. As a result of the literature review, it was that tooth autotransplantation is an effective biological method for the replacement of missing teeth, demonstrating high clinical success rates, preservation of the alveolar bone, and excellent functional and aesthetic outcomes. These findings emphasize the need for broader implementation of this method in modern dental practice.
References
Abdou A., Matoug-Elwerfelli M., Nagendrababu V., Nazzal H., Duggal M. Tooth auto-transplantation: A bibliometric analysis analysis of the top 100 mast-cited articles. Dental Traumatology. 2023. Vol. 39(1). P. 64–81 https://doi.org/10.1111/edt.12779
Abela S., Murtadha L., Bister D., Andiappan M., Kwok J. Survival probability of dental autotransplantation of 366 teeth over 34 years within a hospital setting in the United Kingdom. European journal of orthodontics. 2019. Vol. 41(5). P. 551–556. https://doi.org/10.1093/ejo/cjz012
Ajay S. V., Vishnani R. From Concept to Clinical Practice: A Review of Autotransplantation Techniques and Their Impact on Dentistry. Cureus. 2024. Vol. 16(8). P. e66904. https://doi.org/10.7759/cureus.66904
Algubeal H. M., Alanazi A. F., Arafat A. S., Fatani B., Al-Omar A. Autotransplantation of the Lower Posterior Teeth: A Comprehensive Review. Cureus. 2022. Vol. 14(8). P. e27875. https://doi.org/10.7759/cureus.27875
Ambrósio M. F. S., Cançado R. P., Oliveira B. C. G., Masioli M. A., Cunha D. L. Dental autotransplantation as a alternative treatment for the loss of permanent anterior teeth in children. Dental press journal of orthodontics. 2022. Vol. 27(4). P. e22spe4. https://doi.org/10.1590/2177-6709.27.4.e22spe4
Andreasen J. O., Paulsen H. U., Ahlquist Z. Yu, Bayer R., T. A long-term study of 370 autotransplanted premolars. Part IV. Root development subsequent to transplantation. European Journal of Orthodontics. 1990. Vol. 12(1). P. 38–50. https://doi.org/10.1093/ejo/12.1.38
Andreasen J. O., Paulsen H. U., Ahlquist Z. Yu, Bayer R., T., Schwartz O. A long-term study of 370 autotransplanted premolars. Part I. Surgical procedures and standardized techniques for monitoring healing. European journal of orthodontics. 1990. Vol. 12(1). P. 3–13. https://doi.org/10.1093/ejo/12.1.3
Andreasen J. O., Paulsen H. U., Ahlquist Z. Yu, Bayer R., T., Schwartz O. A long-term study of 370 autotransplanted premolars. Part II. Tooth survival and pulp healing subsequent to transplantation. European journal of orthodontics. 1990. Vol. 12(1). P. 14–24. https://doi.org/10.1093/ejo/12.1.14
APFEL H. Preliminary work in transplanting the third molar to the first molar position. Journal of the American Dental Association. 1939. Vol. 48(2). P. 143–150. https://doi.org/10.14219/jada.archive.1954.0024
Aslan B. I., Uçüncü N., Doğan A. Long-term follow-up of a patient with multiple congenitally missing teeth treated with autotransplantation and orthodontics. The Angle orthodontist. 2010. Vol. 80(2). P. 396–404. https://doi.org/10.2319/033109- 184.1
Choi Y. J., Shin S., Kim K. H., Chung C. J. Orthodontic retraction of autotransplanted premolar to replace ankylosed maxillary incisor with replacement resorption. American journal of orthodontics and dentofacial orthopedics: official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics. 2014. Vol. 145(4). P. 514–522. https://doi.org/10.1016/j.ajodo.2013.06.024
Companioni S., Nguyen T., Divaris K., Christensen J. Optimizing donor tooth selection for autotransplantation in the anterior maxilla via CBCT-based root width and crown-root angle measurements. Dental traumatology: official publication of International Association for Dental Traumatology. 2023. Vol. 39 Suppl 1. P. 63–69. https://doi.org/10.1111/edt.12847
Day P. F., Lewis B. R., Spencer R. J., Barber S. K., Duggal M. The design and development of surgical templates for premolar transplants in adolescents. International endodontic journal. 2012. Vol. 45(11). P. 1042–1052. https://doi.org/10.1111/j.1365-2591.2012.02077.x
Demir T., Ates U., Cehreli B., Cehreli Z. C. Autotransplantation of a supernumerary incisor as a replacement for fused tooth: 24-month follow-up. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics. 2008. Vol. 106(4). P. e1–e6. https://doi.org/10.1016/j.tripleo.2008.06.004
Dioguardi M., Quarta C., Sovereto D., Troiano G., Melillo M., Di Cosola M., Cazzolla A. P., Laino L., Lo Muzio L. Autotransplantation of the Third Molar: A Therapeutic Alternative to the Rehabilitation of a Missing Tooth: A Scoping Review. Bioengineering (Basel, Switzerland). 2021. Vol. 8(9). P. 120. https://doi.org/10.3390/bioengineering8090120
Elani H. W., Starr J. R., Da Silva J. D., Gallucci G. O. Trends in Dental Implant Use in the U.S., 1999-2016, and Projections to 2026. Journal of dental research. 2018. Vol. 97(13). P. 1424–1430. https://doi.org/10.1177/0022034518792567
Freitas Coutinho N. B., Nunes F. C., Gagno Intra J. B., Roldi A., Jesus-Soares A., Coelho M. S., Frozoni M. Success, Survival Rate, and Soft Tissue Esthetic of Tooth Autotransplantation. Journal of endodontics. 2021. Vol. 47(3). P. 391–396. https://doi.org/10.1016/j.joen.2020.11.013
Grisar K., Chaabouni D., Romero L. P. G., Vandendriessche T., Politis C., Jacobs R. Autogenous transalveolar transplantation of maxillary canines: a systematic review and meta-analysis. European journal of orthodontics. 2018. Vol. 40(6). P. 608–616. https://doi.org/10.1093/ejo/cjy026
Han B., Liu L., Jiang Z., Ye L., Cao Y., Pan J. Efficacy of root canal treatment for autotransplanted third molars: a 6-Year cohort study of 167 teeth in southern China. PeerJ. 2025. Vol. 13. P. e18824. https://doi.org/10.7717/peerj.18824
Hariri R., Alzoubi E. E. M. Autotransplantation in combination with orthodontic treatment. Journal of orthodontic science. 2019. Vol. 8. P. 11. https://doi.org/10.4103/jos.JOS_62_18
Howe M. S., Keys W., Richards D. Long-term (10-year) dental implant survival: A systematic review and sensitivity meta-analysis. Journal of dentistry. 2019. Vol. 84. P. 9–21. https://doi.org/10.1016/j.jdent.2019.03.008
Jaber M., Prasad P., Akeil M., Moufti A., Al-Sammarraie A., Charaf Eddin C. Long-Term Evaluation of Tooth Transplantation: An Umbrella Review. Journal of clinical medicine. 2024. Vol. 13(11). P. 3341. https://doi.org/10.3390/jcm13113341
Kakde K., Rajanikanth. K. Tooth Autotransplantation as an Alternative Biological Treatment: A Literature Review. Cureus. 2022. Vol. 14(10). P. e30491. https://doi.org/10.7759/cureus.30491
Kim E., Jung J. Y., Cha I. H., Kum K. Y., Lee S. J. Evaluation of the prognosis and causes of failure in 182 cases of autogenous tooth transplantation. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics. 2005. Vol. 100(1). P. 112–119. https://doi.org/10.1016/j.tripleo.2004.09.007
Kinaia B. M., Hasso D. F., Jirjis L., Zora J. S., Azimi K., Akkad L., Agarwal K., Kaspo G., Neely A. L., Al-Qawasmi R. Supernumerary tooth autotransplantation to replace missing maxillary central incisor using three-dimensional replica: A 6-year follow-up. International orthodontics. 2022. Vol. 20(2). P. 100635. https://doi.org/10.1016/j.ortho.2022.100635
Kvint S., Lindsten R., Magnusson A., Nilsson P., Bjerklin K. Autotransplantation of teeth in 215 patients. A follow-up study. The Angle orthodontist. 2010. Vol. 80(3). P. 446–451. https://doi.org/10.2319/062509-354.1
Louropoulou A., Andreasen J. O., Leunisse M., Eggink E., Linssen M., Van der Weijden F., Barendregt D. An evaluation of 910 premolars transplanted in the anterior region-A retrospective analysis of survival, success, and complications. Dental traumatology: official publication of International Association for Dental Traumatology. 2024. Vol. 40(1). P. 22–34. https://doi.org/10.1111/edt.12887
Lucas-Taulé E., Bofarull-Ballús A., Llaquet M., Mercade M., Hernández-Alfaro F., Gargallo-Albiol J. Does Root Development Status Affect the Outcome of Tooth Autotransplantation? A Systematic Review and Meta-Analysis. Materials. 2022. Vol. 15(9). P. 3379. https://doi.org/10.3390/ma15093379
Lucas-Taulé E., Llaquet M., Muñoz-Peñalver J., Nart J., Hernández-Alfaro F., Gargallo-Albiol J. Mid-term outcomes and periodontal prognostic factors of autotransplanted third molars: A retrospective cohort study. Journal of periodontology. 2021. Vol. 92(12). P. 1776–1787. https://doi.org/10.1002/JPER.21-0074
Mourão C.F., Resende R. Dental autotransplantation: a viable solution for preserving oral health and function. Evid Based Dent. 2024. Vol. 25. P. 77–78. https://doi.org/10.1038/s41432-024-01002-w
Natiella J. R., Armitage J. E., Greene G. W. The replantation and transplantation of teeth. A review. Oral surgery, oral medicine, and oral pathology. 1970. Vol. 29(3). P. 397–419. https://doi.org/10.1016/0030-4220(70)90143-x
Nimčenko T., Omerca G., Varinauskas V., Bramanti E., Signorino F., Cicciù M. Tooth auto-transplantation as an alternative treatment option: A literature review. Dental research journal. 2013. Vol. 10(1). P. 1–6. https://doi.org/10.4103/1735-3327.111756
Ong D., Itskovich Y., Dance G. Autotransplantation: a viable treatment option for adolescent patients with significantly compromised teeth. Australian dental journal. 2016. Vol. 61(4). P. 396–407. https://doi.org/10.1111/adj.12420
Ong D. V., Goh P., Dance G. Anterior tooth autotransplantation: a case series. Australian dental journal. 2023. Vol. 68(3). P. 202–215. https://doi.org/10.1111/adj.12966
Park J. H., Tai K., Hayashi D. Tooth autotransplantation as a treatment option: a review. The Journal of clinical pediatric dentistry. 2010. Vol. 35(2). P. 129–135. https://doi.org/10.17796/jcpd.35.2.97816254u2140x88
Parvini P., Obreja K., Trimpou G., Mahmud S., Sader R. Autotransplantation of teeth. The international journal of esthetic dentistry. 2018. Vol. 13(2). P. 274–282.
Pedrinaci I., Calatrava J., Couso-Queiruga E., Bethencourt J. D. R., Sanz-Sanchez I., Gallucci G. O., Sanz M. Tooth autotransplantation with adjunctive application of enamel matrix derivatives using a digital workflow: A prospective case series. Journal of dentistry. 2024. Vol. 148. P. 105131. https://doi.org/10.1016/j.jdent.2024.105131
Piroozmand F., Hessari H., Shirazi M., Khazaei P. Autotransplantation and Orthodontic Treatment after Maxillary Central Incisor Region Trauma: A 13-Year Follow-Up Case Report Study. Case reports in dentistry. 2018. Vol. 2018. P. 2039714. https://doi.org/10.1155/2018/2039714
Plakwicz P., Andreasen J. O., Górska R., Burzykowski T., Czochrowska E. Status of the alveolar bone after autotransplantation of developing premolars to the anterior maxilla assessed by CBCT measurements. Dental traumatology: official publication of International Association for Dental Traumatology. 2021. Vol. 37(5). P. 691–698. https://doi.org/10.1111/edt.12680
Plotino G., Abella Sans F., Duggal M. S., Grande N. M., Krastl G., Nagendrababu V., Gambarini G. Clinical procedures and outcome of surgical extrusion, intentional replantation and tooth autotransplantation – a narrative review. International endodontic journal. 2020. Vol. 53(12). P. 1636–1652. https://doi.org/10.1111/iej.13396
Rugani P., Kirnbauer B., Mischak I., Ebeleseder K., Jakse N. Extraoral Root-End Resection May Promote Pulpal Revascularization in Autotransplanted Mature Teeth-A Retrospective Study. Journal of clinical medicine. 2022. Vol. 11(23). P. 7199. https://doi.org/10.3390/jcm11237199
Sezer B., Şen Yavuz B., Korkut B., Menteş A. Nine-year Follow-up of Autotransplantation in the Maxillary Anterior Region: Replacing a Fused Incisor with a Supernumerary Tooth. Journal of endodontics. 2025. Vol. 51(6). P. 781–787. https://doi.org/10.1016/j.joen.2025.02.003
Shi H. A., Siow S. F. D., Phua Z. Y. J. Tooth autotransplantation in a patient with rapidly progressing periodontitis aided by 3D printing. BMJ case reports. 2021. Vol. 14(8). P. e243601. https://doi.org/10.1136/bcr-2021-243601
Sicilia-Pasos J., Kewalramani N., Peña-Cardelles J. F., Salgado-Peralvo A. O., Madrigal-Martínez-Pereda C., López- Carpintero Á. Autotransplantation of teeth with incomplete root formation: systematic review and meta-analysis. Clinical oral investigations. 2022. Vol. 26(5). P.3795–3805. https://doi.org/10.1007/s00784-022-04435-8
Singh A. K., Khanal N., Acharya N., Hasan M. R., Saito T. What Are the Complications, Success and Survival Rates for Autotransplanted Teeth? An Overview of Systematic Reviews and Metanalyses. Healthcare (Basel, Switzerland). 2022. Vol. 10(5). P. 835. https://doi.org/10.3390/healthcare10050835
Tan B. L., Tong H. J., Narashimhan S., Banihani A., Nazzal H., Duggal M. S. Tooth autotransplantation: An umbrella review. Dental traumatology : official publication of International Association for Dental Traumatology. 2023. Vol. 39 Suppl 1. P. 2–29. https://doi.org/10.1111/edt.12836
Tankittiwat P., Thittiwong R., Limmonthol S., Suwannarong W., Kupradit P., Prajaneh S., Pisek P. Mandibular premolar transplantation to replace missing maxillary anterior teeth: A multidisciplinary approach. American journal of orthodontics and dentofacial orthopedics. 2021. Vol. 160(3). P. 459–472. https://doi.org/10.1016/j.ajodo.2020.06.035
Third Molar Autotransplantation: An Alternative to Dental Implant – 9 Years Follow up of a Case. Kumar S., Jain M., Sogi S., Shahi P., Dhir S., Rana S. Annals of maxillofacial surgery. 2020. Vol. 10(2). P. 529–532. https://doi.org/10.4103/ams.ams_237_19
Tiigimäe-Saar J. Multiple-tooth autotransplantation patients: Long-term (4-8 years) results of treatment. Stomatologija. 2023. Vol. 25(3). P. 63–70.
Tsukiboshi M. Autotransplantation of teeth: requirements for predictable success. Dental traumatology: official publication of International Association for Dental Traumatology. 2002. Vol. 18(4). P. 157–180. https://doi.org/10.1034/j.1600-9657.2002.00118.x
Tsukiboshi M., Tsukiboshi C., Levin L. A step-by step guide for autotransplantation of teeth. Dental traumatology: official publication of International Association for Dental Traumatology. 2023. Vol. 39 Suppl 1. P. 70–80. https://doi.org/10.1111/edt.12819
Verweij J. P., Jongkees F. A., Anssari Moin D., Wismeijer D., Merkesteyn J. P. R. Autotransplantation of teeth using computeraided rapid prototyping of a three-dimensional replica of the donor tooth: a systematic literature review. International journal of oral and maxillofacial surgery. 2017. Vol. 46(11). P. 1466–1474. https://doi.org/10.1016/j.ijom.2017.04.008
Verweij J. P., Moin D. A., Mensink G., Nijkamp P., Wismeijer D., Merkesteyn J. P. Autotransplantation of Premolars With a 3-Dimensional Printed Titanium Replica of the Donor Tooth Functioning as a Surgical Guide: Proof of Concept. Journal of oral and maxillofacial surgery: official journal of the American Association of Oral and Maxillofacial Surgeons. 2016. Vol. 74(6). P. 1114–1119. https://doi.org/10.1016/j.joms.2016.01.030
Vilhjálmsson V. H., Knudsen G. C., Grung B., Bårdsen A. Dental auto-transplantation to anterior maxillary sites. Dental traumatology: official publication of International Association for Dental Traumatology. 2011. Vol. 27(1). P. 23–29. https://doi.org/10.1111/j.1600-9657.2010.00952.x
Wu Y., Chen J., Xie F., Liu H., Niu G., Zhou L. Autotransplantation of mature impacted tooth to a fresh molar socket using a 3D replica and guided bone regeneration: two years retrospective case series. BMC oral health. 2019. Vol. 19(1). P. 248. https://doi.org/10.1186/s12903-019-0945-8
Züger M., Mukkadam K., Filippi A., Schmidlin P. R. Periodontal status after autologous tooth transplantation (ATT) of premolars and wisdom teeth: A systematic review. SWISS DENTAL JOURNAL SSO – Science and Clinical Topics. 2024. Vol. 134(4). P. 54–71. https://doi.org/10.61872/sdj-2024-04-05
